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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ab1860051f957781a147b4d86e48f6e046d18da176c3b97b441693176b128d' 
  AND token = 'sj4IgeQrmvD4aX7pc30Ll+SiwTC0xhlUjIJtxbpI0fk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00052

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}