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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b0e228fe16e7c10e3b9e887601fbb181973565edb6847ec545a7f7b15b47fab' 
  AND token = 'xdI9cv+rcdoE/w2zr5SWk+aAaO702cvBqRtYQIw5ZTA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00048

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}