SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0221a3c75b570a121218fa43ecb6b31f08adb65876e9a26e13b8fdc557d9b1a0' 
  AND token = 'XJKW5lAPjwAsNEkDfzZ0TSnh3/gTTuXbpZBhEEigmaw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}