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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2423596a3af3ffb8be02bddce302cd7d63116c3c4b2c2acf4971e2aca15018d' 
  AND token = 'P9IegxsFLTJ2SRnXEQGwgTtNNCL+7tmZLMZgTp+k9kg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}