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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ff50f4a3e71c7f949c8a5b2ef3272dee6708b075d9b083e190f0a1d083a77921' 
  AND token = 'yPULYXrwSrSgZOwlXfH+c2EoUlvoaQOcQl8IXhKxgeQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}