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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25e5f933e9fde5652f8c76d65e4e6d10064d648ca9b61c7f6b1bc303848ebeaa' 
  AND token = '/klViqLLIXDyCHCbHyCapARAd43F4OTqz2MPVnzf/OE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}