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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5206adeaaaf93e8716dbe7649fe48f4f2e04fc9a99b295227ec13b95f3721622' 
  AND token = 'irtd6afuhXfRCG6PkuNu29qqmFB13lcd8K+kKa0WbUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}