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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aa5f21ef86361b44a69a7b9138249a340d5634e957cc18011299e23f96b402e9' 
  AND token = '22ERY3dfeLeyC0YzO9U+s0b1RBDWGuSpQtFZzyIxCoE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}