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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eefbd040fa217f7d42371c929e044e8629b5ca7db4587b5d6c269fe921fd2e91' 
  AND token = 'CEGbSKn/JHtrcbQorHSM6k9tnqA/ZmZQCW1d5XoPqXw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}