SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e228ccf0f89b6872a91dde07c4898226e8e563949e5791131e605081866c0f07' 
  AND token = 'oCzKydqCWMcU4mdGCUCuhlz2Kv3IpGh2eSBnSRdRLws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}