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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8227c22f2597d6e120306e393a46217522c49e8ff8333fce1ba9ebc9759adaac' 
  AND token = 'dOE4df9UVeBQfNKLJXG0h0F+L5DVBVSClJAC5LMthm8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}