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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80f4eaab35956d0d1ca014151e78ea8f10a273cdc5bec8a758fde78a5f31aa48' 
  AND token = 'PR8SAx70GQ1Y4IPbb8+8d1xNnR029YLMyLQhXT5aQY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}