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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a3fc50eafac34cf069b393956de6d6dd423acd4d2ac2b7c3fb4f3cb409b132f' 
  AND token = 'rbUWn8q3fxDm1KUDF2wr4oKpGOjLzgiATmNCFMS4QoU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}