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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c69543aa61e384f85199676269ce5dc7e517c9377e671b519d3c7b9b20bf9a03' 
  AND token = 'yEB7vAbs1q8e7i/3MsAzjDcEZG1GIOAsEciSgGSqu3k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}