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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4bc1fe9f4881a542cea16d41e8ce4e265167d9f77af25669c3446def607b9f59' 
  AND token = 's1LNVf4GzrDLn9kUDGnAyTD3iYjtFLUCOkpp4SkFAzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}