SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '122c3bff074ef7b1ac70a5453e4a9755d27214beb4a001409f8529944ec7c6cf' 
  AND token = 'S3LVqwRHLdnFFhE+RIBPxYy14bgYL0kKVUkfYuRQmkE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}