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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2733782ff63e659517d72cc701ec3a19c957e48fd43edc514b11726c5734e0e3' 
  AND token = 'UlpzMEsUFsAcS+oTbhAuuz1DSIajCMW0Q2+6gPFbZqU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}