SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4cf389547114ba04bbe0b07c7f2cde6c548632b46fac47c6b3ccf6f8b894d0f3' 
  AND token = 'U2ZTSyNm0S0TdsBKsRJUqUomS2h7yCItZmRKCxfXzy0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}