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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4a46aa574d2b61ef2cd4b4fc169dc15e1867c267d9277a0523edbea24d6ccd0' 
  AND token = 'VZjQQ/7t1zT9BCCO89RHxxyRWeDibKA20xSgRw8CXWM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}