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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d166c8051d0d25cd4d99a0d072415a871fe09aedfecfd6342df66780fa27c6f' 
  AND token = 'LQBZylmdWnP8PKPQijI8roGS4eK4IVCQlHK8HqiVybg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00049

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}