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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a22dc50dbefe25ceb064b5a0a8464d2d903296ab8990f28c09b0373b4d2785d' 
  AND token = 'sHLqQWoU/Li90mIPHd7Pm2L+m0+FYbsIGAygcLnZQ94=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}