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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78e3d093f68502042d98fd35382cd0659a37210dba3335fcf4ca03ea184a58c0' 
  AND token = 'sPSvVcfeQHsKmG1rVKHo65xqHH3UJv+u+6XA6zLXSe8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}