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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad0051fd18e00db6b984aebb71c4e68b557dbbaf932795b98a7bfef553684813' 
  AND token = 'LEtKrNoc/x8wMKyFNj7eRT8mF35wd6UvLJvlQ/DWgIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}