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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '421779c8ea6dc4a236786a8eef009f7a51d4f493874869cb3170253a4c124ad3' 
  AND token = 'WjKqD1Be8xHayjH+G6TjyLKcXgqWXBoTZd6V7UQnHi4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}