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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a6a75109af39d65b50a7a134c540496bc10a94fe22a176263e6f40ad7a0bc5ae' 
  AND token = 'jIJs91HRCbJQevVxyxkVPV1Nc6CeN/7b6Y0gbOPnE/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}