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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16b8ff1982940c76c076f8cf2b1e7f2cfb275cac76dc8024182ad4f11c2f817b' 
  AND token = '+Wwkztp+hYJiO4zH1Qw0HFz/YELkVtttJ/BhgVD0tEc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}