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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '757fa8988f9c4b5a128cda3a152f38328ae78cdb72084127532801b569905da0' 
  AND token = 'p1ecqQs8UxWBGLn5ALo9VakcgzMxZFpA4nbcBEtdJt4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}