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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '286306455b53fe5aee1e96ba380f81a9d1d5c309fae41213f88555276f65a768' 
  AND token = 'AEV0PGveEy1+OR1rjcjPzGea6empMFgJW38zNO7dT38=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}