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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c18c4abf6366deef12ec14c895db18abe40e8726b4376f7475700a94df22c306' 
  AND token = 'ldkTVtAv9/2RmghDWB+9mrMmFQtzLSmN6RlXE/AxWAc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}