SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5643933cf8ab95a0598cc8e2526ad69fc86cf7476805a4b1354f1b4d73082767' 
  AND token = 'JimaYX55IGZMmHSSPHRu3WXh2VTtg4QO4XPPLlqf8ug=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}