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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '03e1c72932c6b4bc37142e7f31f44f1356c7c909c02f44fcc404f53e36a0e3a8' 
  AND token = 'MrdwG0JLMg1PUAcP6tn6OF97hGKxF61G2gkAFxNWadk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}