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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21b7a4464b85bfb9c6303eb43b9e658cbcd1c5d862e026dc21c26deaf2b30805' 
  AND token = 'R9NxKMF+FxDCKoIPw25P/q5hhZrwwjVlb6M3uXE12Yk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}