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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c9c15c5e4ee9bcf795b861fb75a1be6120ab068e9270216c645752c33baabc0' 
  AND token = 'BIC8csWpOzZU/LsAoXMnRnVYkl3uVZ/nVqbEwxkivDE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}