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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4001852db451784d8f0e29e247f3f23d3d6c369d4749d3e55549fb54314b098b' 
  AND token = 'XHD2Kx/ESvEOZEtSGFPjnGY5nXsUfTnbmh7TBGWiITk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}