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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b68bc94903d0baef57458d8f2ff6a96b31ab1ed35adf5aabdd6892007c1a6f' 
  AND token = 'uWD/Wg2RKRFB+mjb3PatlcgRMXiKd1vl0/OysY4mwyk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}