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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0521c49468dbb2491443a7a354c27d8dd7c464783cd17d4526342f03b7dc4e7d' 
  AND token = 'pZ0ZOmqX18TbkbLf/o4G9OKzkDt+bMIc1bNUQcMzboU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}