SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8fd665c9c42bf5bf251beebe450364f37c9bed1beea27ceb28c833ca8ac8b262' 
  AND token = 'AGOCCsPFvTNVjN1mTCrADWA+oRqrH1YuSs5VoBrUlXo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}