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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59f2f49e42a9fa05839d08597ce39cfa18a9a9db2169e2ce0360d079b560c682' 
  AND token = 'd4xjZf1jIHhaUBhYC/mUUY6xKIeTAgtXc3uXEGRKxxE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}