SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '746fc1ece1dc3a315af3b27155794dab3e1dadb7e0f9079e06432c80f2036022' 
  AND token = 'WEw3olYoI9raqpfXvyAhIWiMqGZOjcbkwPmeOjdutXs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}