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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c29324160ea5e15ed12a0f6cc1a338566e3c614fc54b879866c327cd278a314' 
  AND token = '/E3IkilVB3ZTku7B2eRNRoecD3aaOz+xhaiwNpbLXNo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}