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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ff572b78e6e8c590e58065e6a35dc9234311425198cb67c85b196e594bc320e' 
  AND token = '9I7w2l2m4VmRB/h3zCia0Y2IYSyW3ceerT7XDcBWoRM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}