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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7d2e56297855c875b2eac7ca7d70028964d09d70e8547a8b6e1483948705e2a8' 
  AND token = 'ED4JzuUhLa3ZOULDrPJQ/+ct6aYEcCVawPdlM7lERy0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}