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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e66aab1c28fba9a9f2d76a5b18f88b1b493ed8db5b9c82bfd77723a1768d7fd7' 
  AND token = 'UvyATUIYKlZhbo6twlKr8WRQ4NRaLU2QWwk04XPbl0E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}