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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b49ab883ac8d226c099864c6423eb3f34d66bf9fb4361fccd3ee3765c2ffad3' 
  AND token = 'drdkdvQeaOXKwtGi8d6wkHUq92ttEZlEObvs8n//464=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}