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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2381f9ae4c4ccaacbf2b3045f30c11eaeea40e579d4c83575007533e266d0d43' 
  AND token = 'hOwHwIovBbC5i5u8calGx6beBN/F2nE2c0XmV+DRyig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}