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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c43a4362f412522453548c29c0e232e97484d4e1d8c20f6d4fd2c3d7605b12' 
  AND token = 'eM/bJf+iunYUE+DynS16Pp0sEaLg84JDMFUqu7snPl8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}