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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e63d8d3022d49296bd9a94082f781bdbd7d9da4629c38dfa0647de1e2e4aec6a' 
  AND token = 'lf2cUpqrLK5S2T4c14b8jIyZKUidj2CC+A/wSaAmvLc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}