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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21dba57c1da3be383c5434ceb36b74a3e4921c47e40b1c2a682a167d3bc5d751' 
  AND token = 'chWywyZOf53RtG7/qWcW+jq8hfyqTiOwlNVMg834wWs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}