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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '486370c7196cb70bb137e4b1b1c8579544068cde94e7be09efd45f2bf0d1c42c' 
  AND token = 'Wj6Oi9R3rXLOJhLQbzRkTAPoSNwEKcOFU6Z29HpOSXU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}