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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e7d159d5bbdfd20129cc70136a8a31c03a89eb8205f25ee3b4d9127736b4330' 
  AND token = 'o2If+ylDKC+/Y0NWuNG7RZdwzS5aCuwoHA8sLZks6Rs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}